药物缓控释体系的研究在材料化学与生物医药领域备受关注。凝胶体系由于其良好的结构可控性、生物相容性和环境响应性等特点,使其成为一类重要的药物缓控释载体。刺激响应性是凝胶药物控释体系有效应用的关键,基于温度、pH值、磁场、光和葡萄糖浓度等环境因素,对凝胶体系在药物控释领域中的研究进展进行了总结与归纳,为环境响应性凝胶的开发与应用提供理论基础。
Controlled drug release and delivery system have drawn much attention in academic and medical areas.Stimuli-responsive hydrogel become a significant category of carrier used in healthcare industry because of their designable structure,excellent biocompatibility and sensible responsibility to different external conditions.Among these advantages,stimuli-responsibility is the essential factor for hydrogel used in controlled drug release.The research progress in hydrogels carrier-drug delivery system depending on stimulated factors such as temperature,pH,magnetic field,light and glucose concentration were summarized.Some details were discussed also.
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基金资助
天津市应用基础与前沿技术研究计划(15JCYBJC18000);天津市应用基础与前沿技术研究计划重点项目(14JCZDJC37200)
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