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摘要
通过溶胶-凝胶法制得壳聚糖(CS)/β-甘油磷酸钠(GP)可注射水凝胶,研究了不同成胶温度对凝胶机械性能、微观形貌、溶胀性能以及药物缓释性能的影响。结果表明,较高的成胶温度使凝胶内氢键作用增强、有效交联密度增大,导致凝胶的机械性能增强,使凝胶的三维网络更加致密,并延缓了药物的释放时间。当成胶温度为60℃时,CS/GP可注射水凝胶抗拉强度为3.13MPa,平衡溶胀率为6.27g/g;制得的CS/GP/阿司匹林(ASA)载药水凝胶的药物释放速率常数为5.09×10-3/min,具有较好的应用前景。
Abstract
Chitosan injectable hydrogels were prepared by sol-gel method,and the effect of gelation temperature on mechanical property,micromorphology,swelling property and the drug release behavior were studied.The results showed that the hydrogen bonding interaction and effective crosslinking density of hydrogel increased with the increasing of gelation temperature,which led to higher mechanical property,denser network structure and superior drug release efficiency.When gelation temperature was 60℃,the tensile strength of CS/GP hydrogel was 3.13MPa,the equilibrium swelling ratio was 6.27g/g.The drug release rate constant of CS/GP/aspirin (ASA) carrier hydrogel was 5.09×10-3/min,which showed better application prospect.
关键词
壳聚糖可注射水凝胶
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成胶温度
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交联密度
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药物缓释
Key words
chiosan injectable hydrogel
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gelation temperature
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crosslinking density
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drug release
壳聚糖可注射水凝胶制备及药物缓释行为[J].
化工新型材料, 2017, 45(9): 150-152 DOI:
[1] 李萌,马霞,马巧燕,等.甲壳素及其衍生物的制备与应用[J].广东化工,2015,21(21):97-98.
[2] Chenite A,Chaput C,Wang D,et al.Novel injectable neutral solutions of chitosan form biodegradable gels in situ[J].Biomaterials,2000,21(21):2155-2161.
[3] 马勇,陈金飞,张允申,等.可注射性壳聚糖/β-甘油磷酸二钠凝胶复合同种异体软骨细胞修复兔膝关节软骨缺损及威灵仙的干预效应[J].中国组织工程研究,2010,14(16):2864-2869.
[4] Cheng Y H,Yang S H,Lin F H.Thermosensitive chitosan-gelatin-glycerol phosphate hydrogel as a controlled release system of ferulic acid for nucleus pulposus regeneration[J].Biomaterials,2011,32(29):6953-6961.
[5] 马君义,陈香玲,盛爱霞,等.载高乌甲素可注射壳聚糖/β-甘油磷酸钠温敏水凝胶的制备与性能研究[J].中国药学杂志,2015,50(19):1696-1703.
[6] Xiang Y Q,Peng Z Q,Chen D J.A new polymer/clay nano-composite hydrogel with improved response rate and tensile mechanical properties[J].European Polymer Journal,2006,42(9):2125-2132.
[7] Tang Y F,Wang X Y,Li Y,at al.Production and characterisation of novel injectable chitosan/methylcellulose/salt blend hydrogels with potential application as tissue engineering scaffolds[J].Carbohydrate Polymers,2010,82(3):833-841.
[8] 胡盛,苏阳,田大听,等.壳聚糖/凹凸棒石纳米复合材料的制备与表征[J].化工新型材料,2013,41(12):149-151.
[9] 刘昌孝.实用药物动力学[M].北京:中国医药科技出版社,2003,3-4.
