Hydrogel has attracted more and more attention as a new functional polymer material with application value and economic benefit.Chitosan hydrogel was prepared by free radical graft copolymerization using natural biodegradable polymer chitosan as the carrier.The properties on adsorption and drug controlled release of chitosan hydrogel were studied.The experimental results showed that the hydrogel can be completely degraded for about 20 days,which indicated it with good degradation performance.The adsorption capacity of the hydrogel on copper ions showed that the equilibrium adsorption capacity was up to 225.8mg/g at 25℃,when the concentration of copper ions was 800mg/L.The controlled release results showed that temperature and initial drug dosage had great influence on the controlled release performance,with methylene blue as the drug model.The cumulative release rate reached about 70% in 48h,which may achieve sustained release and controlled release to a certain extent.
[1] Lee K Y,Mooney D J.Hydrogels for tissue engineering[J].Chemical Reviews,2001,101(7):1869-1880.
[2] Mukhopadhyay P,Sarkar K,Bhattacharya S,et al.pH sensitive N-succinyl chitosan grafted polyacrylamide hydrogel for oral insulin delivery[J].Carbohydrate Polymers,2014,112(2):627-637.
[3] Birch N P,Barney L E,Pandres E,et al.Thermal-responsive behavior of a cell compatible chitosan/pectin hydrogel[J].Biomacromolecules,2015,16:1837-1843.
[4] Ma Y M,Wei D X,Yao H.Synthesis,characterization and application of thermoresponsive polyhydroxyalkanoate-graft-poly(N-isopropylacrylamide)[J].Biomacromolecules,2016,17:2680-2690.
[5] Tsao C T,Kievit F M,Wang K,et al.Chitosan-based thermoreversible hydrogel as an in vitro tumor microenvironment for testing breast cancer therapies[J].Molecular Pharmaceutics,2014,11:2134-2142.
[6] Hoare T R,Kohane D S.Hydrogels in drug delivery:progress and challenges[J].Polymer,2008,49(8):1993-2007.
[7] Yang J A,Kim H,Park K,et al.Molecular design of hyaluronic acid hydrogel networks for long-term controlled delivery of human growth hormone[J].Soft Matter,2011,7(3):868-870.
[8] Jin R,Moreira Teixeira L S,Dijkstra P J,et al.Injectable chitosan-based hydrogels for cartilage tissue engineering[J].Biomaterials,2009,30(13):2544-2551.
[9] Martin A F,Facchi S P,Follmann H D M,et al.Antimicrobial activity of chitosan derivatives containing N-quaternized moieties in its backbone:a review[J].International Journal of Molecular Sciences,2014,15:20800-20832.
[10] Loo Y H,Hauser C A E.Bioprinting synthetic self-assembling peptide hydrogels for biomedical application[J].Biomedical Materials,2016,11:1-7.
[11] Benhabiles M S,Salah R,Lounici H,et al.Antibacterial activity of chitin,chitosan and its oligomers prepared from shrimp shell waste[J].Food Hysrocolloids,2012,29:48-56.
[12] Zhang Y,Zhang M Q.Three-dimensional macroporous calcium phosphate bioceramics with nested chitosan sponges for load-bearing bone implants[J].Journal of Biomedical Materials Research,2002,61:1-8.
[13] Balakrishnan B,Banerjee R.Biopolymer-based hydrogels for cartilage tissue engineering[J].Chemical Reviews,2011,111(8):4453-4474.
[14] Liu C,Thormann E,Claesson P M,et al.Surface grafted chitosan gels.part Ⅱ.gel formation and characterization[J].Langmuir,2014,30:8878-8888.
[15] Bhattarai N,Gunn J,Zhang M.Chitosan-based hydrogels for controlled,localized drug delivery[J].Advanced Drug Delivery Reviews,2010,62(1):83-99.