Abstract: The ciprofloxacin hydrochloride and polyacrylamide hydrogels system with hydrophobic silica particles core and shell structures were prepared by simply rolling method and used to control sustained-release of ciprofloxacin hydrochloride.The effects of the amount of cross linker,the sustained-release medium and the volume of liquid marbles on the sustained-release property of ciprofloxacin hydrochloride was investigated.The results showed that the release concentration of ciprofloxacin hydrochloride of liquid marbles in acidic solution was significantly higher than that in water.Under the conditions of 0.06g ammonium persulfate and 0.05g cross-linking agent in 0.05mol/L HCl solution,the release rate of ciprofloxacin hydrochloride from 20μL liquid marbles was 96.57%,which perform the highest release rate.
韩帅, 王彩霞, 贺拥军, 高健强. 利用液体弹珠制备可控制的缓释凝胶研究[J]. 化工新型材料, 2019, 47(7): 262-265.
Han Shuai, Wang Caixia, He Yongjun, Gao Jianqiang. Study on preparation of controllable sustained-release hydrogel by liquid marbles. New Chemical Materials, 2019, 47(7): 262-265.
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