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化工新型材料  2019, Vol. 47 Issue (7): 262-265    
  开发与应用 本期目录 | 过刊浏览 | 高级检索 |
利用液体弹珠制备可控制的缓释凝胶研究
韩帅, 王彩霞, 贺拥军*, 高健强
西安科技大学化学与化工学院,西安710054
Study on preparation of controllable sustained-release hydrogel by liquid marbles
Han Shuai, Wang Caixia, He Yongjun, Gao Jianqiang
College of Chemistry and Chemical Engineering,Xi'an University of Science and Technology,Xi'an 710054
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摘要 通过简单滚动法制备得以盐酸环丙沙星和聚丙烯酰胺为核,疏水二氧化硅为壳的壳-核结构液体弹珠,并用于盐酸环丙沙星的缓释。研究了交联剂的用量、缓释介质以及液体弹珠的体积对盐酸环丙沙星缓释性能的影响。结果表明,将液体弹珠置于酸性溶液中,盐酸环丙沙星的释放浓度明显高于水,在0.05mol/L HCl溶液中,过硫酸铵用量为0.06g,交联剂用量为0.05g条件下,制得的体积为20μL的液体弹珠的盐酸环丙沙星的释放率最高达到96.57%,具有较好的药物释放性能。
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韩帅
王彩霞
贺拥军
高健强
关键词:  液体弹珠  盐酸环丙沙星  聚丙烯酰胺  缓释  水凝胶    
Abstract: The ciprofloxacin hydrochloride and polyacrylamide hydrogels system with hydrophobic silica particles core and shell structures were prepared by simply rolling method and used to control sustained-release of ciprofloxacin hydrochloride.The effects of the amount of cross linker,the sustained-release medium and the volume of liquid marbles on the sustained-release property of ciprofloxacin hydrochloride was investigated.The results showed that the release concentration of ciprofloxacin hydrochloride of liquid marbles in acidic solution was significantly higher than that in water.Under the conditions of 0.06g ammonium persulfate and 0.05g cross-linking agent in 0.05mol/L HCl solution,the release rate of ciprofloxacin hydrochloride from 20μL liquid marbles was 96.57%,which perform the highest release rate.
Key words:  liquid marble    ciprofloxacin hydrochloride    polyacrylamide    sustained-release    hydrogel
收稿日期:  2018-02-01                出版日期:  2019-07-20      发布日期:  2019-08-05      期的出版日期:  2019-07-20
基金资助: 国家自然科学基金(50572088)
通讯作者:  贺拥军(1967-),男,博士生导师,主要研究纳米材料学   
作者简介:  韩帅(1991-),男,硕士,主要研究方向为材料学
引用本文:    
韩帅, 王彩霞, 贺拥军, 高健强. 利用液体弹珠制备可控制的缓释凝胶研究[J]. 化工新型材料, 2019, 47(7): 262-265.
Han Shuai, Wang Caixia, He Yongjun, Gao Jianqiang. Study on preparation of controllable sustained-release hydrogel by liquid marbles. New Chemical Materials, 2019, 47(7): 262-265.
链接本文:  
http://www.hgxx.org/CN/  或          http://www.hgxx.org/CN/Y2019/V47/I7/262
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