Abstract: A dual sensitive chitosan grafted polymer (CS-g-PNIPAM) was synthesized used chitosan with good biocompatibility and pH sensitivity as the substrate,grafting thermosensitive polymer by combined with reversible addition and fracture chain transfer (RAFT) polymerization.The structure and morphology of grafted polymer was characterized by fourier transform infrared spectroscopy (FT-IR),scanning electron microscopy (SEM),transmission electron microscopy (TEM) and nuclear magnetic resonance (1H-NMR).The temperature sensitivity of block polymer was investigated by UV irradiation.Used to wrap anticancer drug paclitaxel,the results showed that CS-g-PNIPAM with low critical solution temperature (LCST) of 30℃ and average particle size of 100nm was successfully prepared.CS-g-PNIPAM-PTX NPs had a relatively high drug loading efficiency (8.1%).At pH 7.4 and 25℃,the release of PTX was slow but significantly accelerated at pH 5.0 and 37℃.
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