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化工新型材料  2019, Vol. 47 Issue (3): 236-241    
  开发与应用 本期目录 | 过刊浏览 | 高级检索 |
双敏感性壳聚糖接枝聚合物的制备及载药性能研究
钱倩倩,牛世伟,章学易,朱利民*
东华大学化学化工与生物工程学院,上海201620
Preparation and drug loading of double-sensitive chitosan grafted polymer
Qian Qianqian, Niu Shiwei ,Zhang Xueyi ,Zhu Limin
College of Chemistry,Chemical Engineering and Biotechnology,Donghua University, Shanghai 201620
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摘要 以具有良好生物相容性和pH敏感性的壳聚糖(CS)为基材,结合可逆加成断裂链转移(RAFT)聚合接枝温敏性聚合物N-异丙基丙烯酰胺(NIPAM),合成一种双敏感的CS接枝聚合物(CS-g-PNIPAM)。用傅里叶红外光谱仪(FT-IR)、扫描电子显微镜(SEM)、透射电镜(TEM)、核磁(H1NMR)对聚合物的结构和形态进行表征,用变温紫外考察其温敏性,并用来包裹抗癌药物紫杉醇(PTX)。通过物理吸附的方式,将抗癌药物PTX包裹进CS-g-NIPAM纳米颗粒(NPs)中制备载药纳米颗粒(CS-g-PNIPAM-PTX)。实验结果表明,CS-g-PNIPAM成功制备,低临界溶解温度(LCST)为30℃,平均粒径为100nm;载药纳米颗粒CS-g-PNIPAM-PTXNPs具有相对较高的药物负载效率(8.1%),在pH=7.4和25℃时,PTX的释放缓慢;但在pH=5.0和37℃时,释放速度大大加快。
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钱倩倩
牛世伟
章学易
朱利民
关键词:  壳聚糖  RAFT聚合  温敏性  药物缓释    
Abstract: A dual sensitive chitosan grafted polymer (CS-g-PNIPAM) was synthesized used chitosan with good biocompatibility and pH sensitivity as the substrate,grafting thermosensitive polymer by combined with reversible addition and fracture chain transfer (RAFT) polymerization.The structure and morphology of grafted polymer was characterized by fourier transform infrared spectroscopy (FT-IR),scanning electron microscopy (SEM),transmission electron microscopy (TEM) and nuclear magnetic resonance (1H-NMR).The temperature sensitivity of block polymer was investigated by UV irradiation.Used to wrap anticancer drug paclitaxel,the results showed that CS-g-PNIPAM with low critical solution temperature (LCST) of 30℃ and average particle size of 100nm was successfully prepared.CS-g-PNIPAM-PTX NPs had a relatively high drug loading efficiency (8.1%).At pH 7.4 and 25℃,the release of PTX was slow but significantly accelerated at pH 5.0 and 37℃.
Key words:  chitosan    RAFT polymerization    thermosensitiver    drug sustained-release
               出版日期:  2019-03-20      发布日期:  2019-03-20      期的出版日期:  2019-03-20
基金资助: 国家自然科学基金资助项目(21303014);中央高校基本科研业务经费,东华-伦敦都市大学中英药用纺织品联合实验室
通讯作者:  朱利民,教授。   
作者简介:  钱倩倩(1994-),女,硕士研究生,主要研究方向为生物材料和药物缓释。
引用本文:    
钱倩倩,牛世伟,章学易,朱利民. 双敏感性壳聚糖接枝聚合物的制备及载药性能研究[J]. 化工新型材料, 2019, 47(3): 236-241.
Qian Qianqian, Niu Shiwei ,Zhang Xueyi ,Zhu Limin. Preparation and drug loading of double-sensitive chitosan grafted polymer. New Chemical Materials, 2019, 47(3): 236-241.
链接本文:  
http://www.hgxx.org/CN/  或          http://www.hgxx.org/CN/Y2019/V47/I3/236
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