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化工新型材料  2019, Vol. 47 Issue (6): 263-266    
  开发与应用 本期目录 | 过刊浏览 | 高级检索 |
一种新型填料在97%盐酸小檗碱原药测试中的应用
岳瑞丰1, 邱利平2, 荆伟科1
1.河南应用技术职业学院化学工程学院,郑州450042;
2.延长石油产品经销公司,西安710054
Application of a novel filler in the test of 97% berberine hydrochloride
Yue Ruifeng1, Qiu Liping2, Jing Weike1
1.College of Chemical Engineering,Henan Vocational College of Applied Technology,Zhengzhou 450042;
2.Yanchang Petroleum Products Marketing Company,Xi'an 710054
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摘要 诱导聚合胶体团聚法(PICA)以其简单快捷、成本低的优点被广泛应用于SiO2核壳微球的制备,但制备过程中易出现团聚和二次成核现象,所制备的核-壳微球单分散性差,粒径不均一,必须进行分级筛分才能够投入使用。通过改进实验方法,优化实验条件,成功解决了上述问题,制备出单分散的核壳SiO2微球。将制备的核壳微球经十八烷基三氯硅烷(C18)改性后装填色谱柱,并将其应用于97%盐酸小檗碱原药测试中,取得了较好的测试效果。
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岳瑞丰
邱利平
荆伟科
关键词:  新型填料  盐酸小檗碱  高效液相色谱  核壳微球    
Abstract: Polymerization-induced colloid aggregation(PICA) method is widely used in the preparation of silica core-shell microspheres because of its simplicity,rapidity and low cost.However,agglomeration and secondary nucleation are easy to occur in the preparation process.Hierarchical sieving is necessary because of its poor monodispersity and uneven particle size.Monodisperse core-shell silica microspheres were prepared by improving the experimental methods and optimizing the experimental conditions.The prepared core-shell microspheres were modified by octadecyl trichlorosilane(C18) and packed into chromatographic column.The microspheres were applied to the determination of 97% berberine hydrochloride and good results were obtained.
Key words:  novel filler    berberine hydrochloride    HPLC    core-shell microsphere
收稿日期:  2018-11-15                出版日期:  2019-06-20      发布日期:  2019-07-05      期的出版日期:  2019-06-20
基金资助: 河南省高等学校重点科研项目(17B410001);河南省高等教育教学改革研究与实践项目(2017SJGLX658);河南省科技发展计划项目(172102310754)
作者简介:  岳瑞丰(1982-),男,硕士,讲师,主要研究方向为化学化工合成与分析测试。
引用本文:    
岳瑞丰, 邱利平, 荆伟科. 一种新型填料在97%盐酸小檗碱原药测试中的应用[J]. 化工新型材料, 2019, 47(6): 263-266.
Yue Ruifeng, Qiu Liping, Jing Weike. Application of a novel filler in the test of 97% berberine hydrochloride. New Chemical Materials, 2019, 47(6): 263-266.
链接本文:  
http://www.hgxx.org/CN/  或          http://www.hgxx.org/CN/Y2019/V47/I6/263
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