Application of a novel filler in the test of 97% berberine hydrochloride
Yue Ruifeng1, Qiu Liping2, Jing Weike1
1.College of Chemical Engineering,Henan Vocational College of Applied Technology,Zhengzhou 450042; 2.Yanchang Petroleum Products Marketing Company,Xi'an 710054
Abstract: Polymerization-induced colloid aggregation(PICA) method is widely used in the preparation of silica core-shell microspheres because of its simplicity,rapidity and low cost.However,agglomeration and secondary nucleation are easy to occur in the preparation process.Hierarchical sieving is necessary because of its poor monodispersity and uneven particle size.Monodisperse core-shell silica microspheres were prepared by improving the experimental methods and optimizing the experimental conditions.The prepared core-shell microspheres were modified by octadecyl trichlorosilane(C18) and packed into chromatographic column.The microspheres were applied to the determination of 97% berberine hydrochloride and good results were obtained.
岳瑞丰, 邱利平, 荆伟科. 一种新型填料在97%盐酸小檗碱原药测试中的应用[J]. 化工新型材料, 2019, 47(6): 263-266.
Yue Ruifeng, Qiu Liping, Jing Weike. Application of a novel filler in the test of 97% berberine hydrochloride. New Chemical Materials, 2019, 47(6): 263-266.
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