Ag/AgO/羧甲基壳聚糖抗菌水凝胶制备及其释药性能研究
官淑敏, 曹渊* , 徐彦芹, 王烨
重庆大学化学化工学院,重庆401331
Preparation and antibacterial property of Ag/AgO/CMCS hydrogel
Guan Shumin, Cao Yuan, Xu Yanqin, Wang Ye
Institute of Chemistry and Chemical Engineering,Chongqing University,Chongqing 401331
摘要 通过银(Ag)/氧化银(AgO)原位沉淀法制备具有pH敏感性的Ag/AgO/羧甲基壳聚糖(CMCS)抗菌水凝胶(Ag/AgO/CMCS)以及载药阿司匹林(ASA)的Ag/AgO/CMCS/ASA载药水凝胶,并对水凝胶的溶胀性能、降解性能、释药性能及抗菌性能的影响进行了研究。制得的Ag/AgO/CMCS/ASA载药凝胶的网络主要通过氢键和分子间作用力交联,交联点Ag主要以单质Ag和Ag2+ 态存在。在缓冲溶液pH=7.4条件下,制得的Ag/AgO/CMCS/ASA载药凝胶在12h内的累计释药量为75.20%,对革兰氏阴性大肠杆菌(E.coli )的抑制率最大达到92.32%,在医疗领域具有广阔的应用前景。
关键词:
银
氧化银
羧甲基壳聚糖
pH敏感性水凝胶
抗菌
Abstract: PH sensitive Ag/AgO/carboxymethyl chitosan (CMCS) bacteriostatic hydrogels (Ag/AgO/CMCS) and Ag/AgO/CMCS/ASA carrier potion gels were prepared by Ag/AgO in situ precipitation method,and the effects of swelling,degradation,drug release and antibacterial properties of hydrogels were studied.The network of Ag/AgO/CMCS/ASA drug-loaded gels produced was mainly cross-linking by hydrogen bonding and intermolecular forces,and the cross-linking silver was mainly present in the elemental Ag and Ag2+ states.Under the condition of buffer solution pH=7.4,the cumulative release amount of Ag/AgO/CMCS/ASA drug-loaded gel was 75.20% within 12h,and the inhibition rate of Gram-negative Escherichia coli (E.coli ) reached the maximum of 92.32%,which had broad application prospects in the medical field.
Key words:
silver
silver oxide
carboxymethyl chitosan
pH sensitive hydrogel
antibacterial property
收稿日期: 2018-01-12
发布日期: 2019-06-17
期的出版日期: 2019-05-20
基金资助: 中央高校基础研究基金(CDJXS10221136)
通讯作者:
曹渊(1963-),男,博士,教授,主要从事高分子水凝胶研究。
作者简介: 官淑敏(1992-),女,硕士,主要从事高分子水凝胶研究。
引用本文:
官淑敏, 曹渊, 徐彦芹, 王烨. Ag/AgO/羧甲基壳聚糖抗菌水凝胶制备及其释药性能研究[J]. 化工新型材料, 2019, 47(5): 167-171.
Guan Shumin, Cao Yuan, Xu Yanqin, Wang Ye. Preparation and antibacterial property of Ag/AgO/CMCS hydrogel. New Chemical Materials, 2019, 47(5): 167-171.
链接本文:
http://www.hgxx.org/CN/
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http://www.hgxx.org/CN/Y2019/V47/I5/167
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