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化工新型材料  2018, Vol. 46 Issue (3): 210-214    
  科学研究 本期目录 | 过刊浏览 | 高级检索 |
以聚乳酸-b-聚乙二醇-b-聚乳酸二丙烯酸酯为交联剂的pH响应型水凝胶的制备及药物控制释放研究
徐亮, 赵景, 陈泽旭, 李松彦, 盛扬, 孙一新, 张嵘*
常州大学材料科学与工程学院,常州213164
Preparation of pH-responsive hydrogel based on triblock copolymer of polyL-lactate and polyethylene glycol for controlled drug release
Xu Liang, Zhao Jing, Chen Zexu, Li Songyan, Sheng Yang, Sun Yixin, Zhang Rong
Material Chemistry Department,School of Materials and Engineering,Changzhou University,Changzhou 213164
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摘要 采用开环聚合的方法合成了两种不同分子量的聚乙二醇-聚乳酸嵌段共聚物二醇,用丙烯酸酯封端后得到大分子交联剂聚乳酸-b-聚乙二醇-b-聚乳酸二丙烯酸酯(PELAMA)。它们与N-异丙基丙烯酰胺(NIPAM)、丙烯酸(AA)及光引发剂混合后由紫外光引发聚合生成了可生物降解的水凝胶聚乙二醇聚乳酸二丙烯酸酯-丙烯酸-N-异丙基丙烯酰胺(PELAMA-AN)。并对PELAMA-AN进行了表征。研究结果表明:PELAMA-AN在pH=7.4、pH=1.2的条件下,溶胀率分别为1000%~2000%、400%~500%,盐酸阿霉素释放10h的累积释放率分别为20%~40%、50%~60%,并且可以随着pH的变化反复切换。PELAMA-AN具有应用于口服药物载体的潜力。
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徐亮
赵景
陈泽旭
李松彦
盛扬
孙一新
张嵘
关键词:  pH响应型水凝胶  平衡溶胀率  可生物降解  药物缓释  聚乳酸嵌段共聚物    
Abstract: Two kinds of triblock copolymer diols of poly L-lactate (PLLA) and polyethylene glycol (PEG) were synthesized by ring-opening polymerization.The copolymers were end-capped with methacrylate to form macro-crosslinker poly (L-lactide)-b-polyethylene glycol-b-poly (L-lactide) dimethacrylates (PELAMA) for preparation of pH-responsive hydrogel poly (PLEAMA-Acrylic acid-N-isopropylacrylamide) (PELAMA-AN) through photo-polymerization using N-isopropylmethacylamide (NIPAM),acrylic acid (AA) as monomers.PELAMA was characterized with FT-IR and 1H-NMR.The swelling ratio of hydrogels in PBS at various pH values was studied.Simultaneously degradation property and the controlled drug release behavior of hydrogels were also investigated.The results showed that PELAMA-ANs were typical pH-responsive hydrogels.The swelling ratio (1000%~2000%) of hydrogels in pH=7.4 PBS was two times bigger than that in acidic environment (pH=1.2)(400%~500%).Meanwhile,the periodically swelling/diswelling property of the hydrogels was observed by switching the pH values.It was found that the release rate of the doxorubicin hydrochloride at acidic condition (20%~40%) was smaller than that in a neutral environment (50%~60%) with in 10h.Also,the hydrogel released drug killed HeLa cells,which indicated that the PELAMA-AN hydrogels had the potential to be used as anticancer drug carriers.
Key words:  pH-responsive hydrogel    equilibrium swelling ratio    biodegradation    controlled drug release    PLLA block copolymer
收稿日期:  2016-12-06                出版日期:  2018-03-20      发布日期:  2018-04-09      期的出版日期:  2018-03-20
基金资助: 国家自然科学基金(21374012);江苏省自然科学基金(BK20160278)
通讯作者:  张嵘(1969-),男,博士,教授,硕士生导师,主要从事功能性高分子材料及生物材料的研究。   
作者简介:  徐亮(1990-),男,硕士,主要从事功能性高分子材料及生物材料的研究。
引用本文:    
徐亮, 赵景, 陈泽旭, 李松彦, 盛扬, 孙一新, 张嵘. 以聚乳酸-b-聚乙二醇-b-聚乳酸二丙烯酸酯为交联剂的pH响应型水凝胶的制备及药物控制释放研究[J]. 化工新型材料, 2018, 46(3): 210-214.
Xu Liang, Zhao Jing, Chen Zexu, Li Songyan, Sheng Yang, Sun Yixin, Zhang Rong. Preparation of pH-responsive hydrogel based on triblock copolymer of polyL-lactate and polyethylene glycol for controlled drug release. New Chemical Materials, 2018, 46(3): 210-214.
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http://www.hgxx.org/CN/  或          http://www.hgxx.org/CN/Y2018/V46/I3/210
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