Please wait a minute...
 首页  期刊简介 期刊订阅 广告合作 联系我们
 
最新录用  |  当期目录  |  过刊浏览  |  热点文章  |  阅读排行
化工新型材料  2018, Vol. 46 Issue (3): 210-214    
  科学研究 本期目录 | 过刊浏览 | 高级检索 |
以聚乳酸-b-聚乙二醇-b-聚乳酸二丙烯酸酯为交联剂的pH响应型水凝胶的制备及药物控制释放研究
徐亮, 赵景, 陈泽旭, 李松彦, 盛扬, 孙一新, 张嵘*
常州大学材料科学与工程学院,常州213164
Preparation of pH-responsive hydrogel based on triblock copolymer of polyL-lactate and polyethylene glycol for controlled drug release
Xu Liang, Zhao Jing, Chen Zexu, Li Songyan, Sheng Yang, Sun Yixin, Zhang Rong
Material Chemistry Department,School of Materials and Engineering,Changzhou University,Changzhou 213164
下载:  PDF (1437KB) 
输出:  BibTeX | EndNote (RIS)      
摘要 采用开环聚合的方法合成了两种不同分子量的聚乙二醇-聚乳酸嵌段共聚物二醇,用丙烯酸酯封端后得到大分子交联剂聚乳酸-b-聚乙二醇-b-聚乳酸二丙烯酸酯(PELAMA)。它们与N-异丙基丙烯酰胺(NIPAM)、丙烯酸(AA)及光引发剂混合后由紫外光引发聚合生成了可生物降解的水凝胶聚乙二醇聚乳酸二丙烯酸酯-丙烯酸-N-异丙基丙烯酰胺(PELAMA-AN)。并对PELAMA-AN进行了表征。研究结果表明:PELAMA-AN在pH=7.4、pH=1.2的条件下,溶胀率分别为1000%~2000%、400%~500%,盐酸阿霉素释放10h的累积释放率分别为20%~40%、50%~60%,并且可以随着pH的变化反复切换。PELAMA-AN具有应用于口服药物载体的潜力。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
徐亮
赵景
陈泽旭
李松彦
盛扬
孙一新
张嵘
关键词:  pH响应型水凝胶  平衡溶胀率  可生物降解  药物缓释  聚乳酸嵌段共聚物    
Abstract: Two kinds of triblock copolymer diols of poly L-lactate (PLLA) and polyethylene glycol (PEG) were synthesized by ring-opening polymerization.The copolymers were end-capped with methacrylate to form macro-crosslinker poly (L-lactide)-b-polyethylene glycol-b-poly (L-lactide) dimethacrylates (PELAMA) for preparation of pH-responsive hydrogel poly (PLEAMA-Acrylic acid-N-isopropylacrylamide) (PELAMA-AN) through photo-polymerization using N-isopropylmethacylamide (NIPAM),acrylic acid (AA) as monomers.PELAMA was characterized with FT-IR and 1H-NMR.The swelling ratio of hydrogels in PBS at various pH values was studied.Simultaneously degradation property and the controlled drug release behavior of hydrogels were also investigated.The results showed that PELAMA-ANs were typical pH-responsive hydrogels.The swelling ratio (1000%~2000%) of hydrogels in pH=7.4 PBS was two times bigger than that in acidic environment (pH=1.2)(400%~500%).Meanwhile,the periodically swelling/diswelling property of the hydrogels was observed by switching the pH values.It was found that the release rate of the doxorubicin hydrochloride at acidic condition (20%~40%) was smaller than that in a neutral environment (50%~60%) with in 10h.Also,the hydrogel released drug killed HeLa cells,which indicated that the PELAMA-AN hydrogels had the potential to be used as anticancer drug carriers.
Key words:  pH-responsive hydrogel    equilibrium swelling ratio    biodegradation    controlled drug release    PLLA block copolymer
收稿日期:  2016-12-06                出版日期:  2018-03-20      发布日期:  2018-04-09      期的出版日期:  2018-03-20
基金资助: 国家自然科学基金(21374012);江苏省自然科学基金(BK20160278)
通讯作者:  张嵘(1969-),男,博士,教授,硕士生导师,主要从事功能性高分子材料及生物材料的研究。   
作者简介:  徐亮(1990-),男,硕士,主要从事功能性高分子材料及生物材料的研究。
引用本文:    
徐亮, 赵景, 陈泽旭, 李松彦, 盛扬, 孙一新, 张嵘. 以聚乳酸-b-聚乙二醇-b-聚乳酸二丙烯酸酯为交联剂的pH响应型水凝胶的制备及药物控制释放研究[J]. 化工新型材料, 2018, 46(3): 210-214.
Xu Liang, Zhao Jing, Chen Zexu, Li Songyan, Sheng Yang, Sun Yixin, Zhang Rong. Preparation of pH-responsive hydrogel based on triblock copolymer of polyL-lactate and polyethylene glycol for controlled drug release. New Chemical Materials, 2018, 46(3): 210-214.
链接本文:  
http://www.hgxx.org/CN/  或          http://www.hgxx.org/CN/Y2018/V46/I3/210
[1] 高青雨,张玉娟,俞贤达.温度及pH敏感性N-乙烯基吡咯烷酮与丙烯酸β-羟基丙酯共聚物/聚(丙烯酸)互穿网络水凝胶的合成及其性能研究[J].高分子学报,2001(3):329-332.
[2] Jiang B,Li B.Tunable drug loading and release from polypeptide multilayer nanofilms[J].Int J Nanomedicine,2009,4(1):37-53.
[3] Medina S H,Chevliakov M V,Tiruchinapally G,et al.Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells[J].Biomaterials,2013,34(19):4655-4666.
[4] 邓超,王荣,陈维,等.具生物活性的快速光交联生物可降解水凝胶的设计合成[J].高分子学报,2013(5):695-704.
[5] Hu X,Wang Y,Zhang L,et al.Redox/pH dual stimuli-responsive degradable Salecan-g-SS-poly(IA-co-HEMA) hydrogel for release of doxorubicin[J].Carbohydrate Polymers,2017,155:242-251.
[6] Pan Y J,Chen Y Y,Wang D R,et al.Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release[J].Biomaterials,2012,33(27):6570-6579.
[7] Hiemstra C,Zhou W,Zhong Z,et al.Rapidly in situ forming biodegradable robust hydrogels by combining stereocomplexation and photopolymerization[J].Journal of the American Chemical Society,2007,129(32):9918-9926.
[8] 冯学鹏,简鹏,丁琳,等.基于聚丙交酯的光固化型可生物降解聚氨酯丙烯酸酯的合成和表征[J].高分子学报,2016(7):949-958.
[1] 周正强, 洪海志, 孙寒雪, 魏慧娟, 牟鹏, 李安. 相变材料的新兴应用[J]. 化工新型材料, 2018, 46(6): 1-4.
[2] 王倩倩,陈大俊. 壳聚糖可注射水凝胶制备及药物缓释行为[J]. 化工新型材料, 2017, 45(9): 150-152.
[3] 王凇,刘亚男,孔祥平,李建忠. L-PLA/S-PLA纤维的制备及其药物缓释性能研究[J]. 化工新型材料, 2017, 45(9): 133-135.
[1] Xiao Yu, Lv Cheng, Zhang Guoyou. Epoxy resin modified by PMMA microsphere wrapped by graphene oxide[J]. New Chemical Materials, 2017, 45(9): 62 -64 .
[2] Su Wei, Ran Meng, Zhang Ai, Sun Yan. Preparation of sulfur-doped microporous carbon and its adsorption property[J]. New Chemical Materials, 2018, 46(4): 161 -164 .
[3] Fan Yingge. Study on preparation and optical property of one-dimensional ZnO nanorod by sol-gel dip coating[J]. New Chemical Materials, 2018, 46(4): 189 -192 .
[4] Zheng Zhen, Ding Chengli, Li Huiping, Fu Jingjing. Synthesis and property of hydrophobic functionalized cotton linter cellulose/SiO2 composite aerogel[J]. New Chemical Materials, 2018, 46(4): 230 -233 .
[5] Lin Yuan. Research status and application progress of thin film solar cells[J]. New Chemical Materials, 2018, 46(6): 57 -60 .
[6] Chen Kai, Wang Qiang, Sun Ting, You Min, Xia Zuxi. Research on impact of chemical etching on superhydrophobic surface property[J]. New Chemical Materials, 2018, 46(6): 206 -209 .
[7] Zheng Dandan, Chang Wei, Xi Qiang, Yu Cuihua. Preparation and photocatalytic activity of Cd1-xZnxS[J]. New Chemical Materials, 2018, 46(5): 181 -183 .
[8] Han Fei, Zong Yue, Di Song, Wang Shaopo. Adsorption of copper ion in aqueous solution by activated boron nitride[J]. New Chemical Materials, 2018, 46(5): 195 -198 .
[9] Chang Lin, Zhao Yuntao, Bi Yinping, Ren Yiwei. Preparation and characterization of sodium polystyrene sulfonate grafted polysulfone forward osmosis membrane[J]. New Chemical Materials, 2018, 46(7): 114 -117 .
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
版权所有 © 《化工新型材料》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持:support@magtech.com.cn